Mammalian Methylation Consortium

Mammalian Methylation Data Browser

Nature has evolved mammalian species of greatly differing lifespans. To resolve the relationship of DNA methylation with maximum lifespan and phylogeny, researchers performed a large-scale cross-species unsupervised analysis. Comparative studies in many species enables the identification of  epigenetic correlates of maximum lifespan and other traits.

Data from the Mammalian Methylation Consortium will be downloadable from GEO and also here:  https://mydata.clockfoundation.org/app/mammalian-consortium-data-browser

 A browser is available at the link above to routinely view and select key datasets of relevance for further research. 

Beyond access to methylation data, additional tools will be made available to enable testing of available epigenetic clocks on each species.  The full data are now available at the link above. The source publication in Science is the following:

A free link to view and download the full text paper is here.

Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, et al. DNA methylation networks underlying mammalian traits. Science 2023;381:eabq5693. https://doi.org/10.1126/science.abq5693.
 

For any questions, please contact a corresponding author or us directly at the Clock Foundation at info@clockfoundation.org.